Direct Aldol-Reduction Process using Difluoromethyl Aryl Ketones and Aryl Aldehydes in the Presence of Potassium tert-Butoxide: One-Pot Efficient Stereoselective Synthesis of Symmetrical and Unsymmetrical anti-2,2-Difluoropropane-1,3-diols

The potassium tert‐butoxide.mediated deprotonation of two difluoromethyl aryl ketones in the presence of aryl aldehydes in anhydrous dimethylformamide (DMF), provides an efficient and stereoselective synthesis of anti‐2,2‐difluoropropane‐1,3‐diols. Both symmetrical and unsymmetrical diols could be p...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2010-11, Vol.352 (16), p.2787-2790
Main Authors: Xu, Wei, Médebielle, Maurice, Bellance, Marie-Hélène, Dolbier Jr, William R.
Format: Article
Language:English
Subjects:
Aldehydes
aldol reaction
Aromatic compounds
Catalysis
diastereoselectivity
difluoromethyl ketones
Diols
fluorine
Ketones
Potassium
Synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The potassium tert‐butoxide.mediated deprotonation of two difluoromethyl aryl ketones in the presence of aryl aldehydes in anhydrous dimethylformamide (DMF), provides an efficient and stereoselective synthesis of anti‐2,2‐difluoropropane‐1,3‐diols. Both symmetrical and unsymmetrical diols could be prepared in moderate to good yields from readily available starting materials.
ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.201000548