Correlations between ictal propagation and response to electrical cortical stimulation: A cortico-cortical evoked potential study

• Published in: Epilepsy research 2012-08, Vol.101 (1), p.76-87
• Main Authors: Enatsu, Rei, Jin, Kazutaka, Elwan, Sherif, Kubota, Yuichi, Piao, Zhe, O’Connor, Timothy, Horning, Karl, Burgess, Richard C, Bingaman, William, Nair, Dileep R
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Cerebral Cortex - physiology; Child; Cortical stimulation; Drug Resistance; Electric Stimulation; Electrocorticography; Electroencephalography; Epilepsies, Partial - physiopathology; Epilepsies, Partial - surgery; Epilepsy; Epilepsy, Generalized - etiology; Epilepsy, Generalized - physiopathology; Epilepsy, Temporal Lobe - drug therapy; Epilepsy, Temporal Lobe - physiopathology; Evoked potential; Evoked Potentials - physiology; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Ictal propagation; Male; Malformations of the nervous system; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Neurosurgical Procedures; Seizures - physiopathology; Young Adult
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2012.03.004

Summary Objective To better understand the process of ictal propagation in epilepsy by using cortico-cortical evoked potential (CCEP), which reveals the brain networks. Methods Intracranial EEG recordings of 11 seizures from 11 patients with pharmacoresistant focal epilepsy were studied to identify the propagation sites and times. Six patients had a history of secondary generalization (Gen (+) group) and five patients did not (Gen (−) group). Thereafter repetitive 1 Hz bipolar electrical stimuli were applied to the ictal onset zones and CCEPs were recorded by averaging electrocorticograms. Results The propagation of contiguous spread was significantly faster than non-contiguous spread ( p = 0.033). In four patients, CCEP amplitudes were significantly larger in the ictal propagation area than out of the propagation area. However, the distribution of CCEP responses was not necessarily consistent with the ictal propagation area as a whole. Furthermore, the ictal propagation areas out of CCEP-positive areas were significantly broader in Gen (+) group than Gen (−) group ( p = 0.017). Conclusion The present findings suggest that contiguous spread is faster than non-contiguous spread, which can be explained by the enhancement of excitability around the ictal onset area. Furthermore, there is a group of fibers that is “closed” during the seizures and secondary generalization might be more associated with the impairment of cortical inhibition over the broad cortical area rather than direct connection.