Effect of intra-abdominal pressure on hepatic microcirculation: Implications of the endothelin-1 receptor

OBJECTIVE:  To investigate the effect of endothelin receptor A (ETA) and endothelin receptor B (ETB) blockade on liver microcirculation and oxygenation during intra‐abdominal pressure (IAP) increase. METHODS:  Fifteen anesthetized pigs were randomized to receive either nonselective endothelin‐1 (ET‐...

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Published in:Journal of digestive diseases 2012-09, Vol.13 (9), p.478-485
Main Authors: SÁNCHEZ-ETAYO, Gerard, BORRAT, Xavier, ESCOBAR, Bibiana, HESSHEIMER, Amelia, RODRIGUEZ-LAIZ, Gonzalo, TAURA, Pilar
Format: Article
Language:English
Subjects:
Abdomen - physiology
Animals
endothelin-1
Female
Hemodynamics
Hyaluronic Acid - blood
intra-abdominal hypertension
liver
Liver - metabolism
Liver Circulation
Microcirculation
Oxygen - metabolism
Pneumoperitoneum, Artificial
Pressure
Random Allocation
Receptor, Endothelin A - physiology
Swine
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Summary:OBJECTIVE:  To investigate the effect of endothelin receptor A (ETA) and endothelin receptor B (ETB) blockade on liver microcirculation and oxygenation during intra‐abdominal pressure (IAP) increase. METHODS:  Fifteen anesthetized pigs were randomized to receive either nonselective endothelin‐1 (ET‐1) blocker tezosentan (TG, n = 7) or saline (CG, n = 8). Helium was insufflated to increase IAP from 0 to 25 mmHg. Stroke volume variability was maintained ≤ 12% with colloid infusion. Total liver blood flow (TLBF), hepatic microcirculatory blood flow (MBF), hepatic tissue oxygenation (HpO2), hyaluronic acid and plasma disappearance rate (PDR) of indocyanine green (ICG) were recorded. RESULTS:  TLBF remained mostly unaltered in both groups at low IAP and decreased only in CG at the IAP of 25 mmHg. As IAP increased, a significant decline in MBF was observed without correlation with cardiac output or TLBF. In CG, HpO2 decreased as early as IAP of 10 mmHg to high levels of pressure. However, in TG the decrease was significant only at the IAP of 25 mmHg. PDR of ICG decreased in both groups at IAP of 25 mmHg (P = 0.046 and P = 0.009 in TG and CG, respectively). These changes correlated with MBF (r = 0.793). CONCLUSION:  Blocking ETA and ETB receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high IAP.
ISSN:1751-2972
1751-2980
DOI:10.1111/j.1751-2980.2012.00613.x