Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding

• Published in: Histopathology 2012-09, Vol.61 (3), p.488-496
• Main Authors: Canney, Aoife L, Kevans, David, Wang, Lai Mun, Hyland, John M P, Mulcahy, Hugh E, O'Donoghue, Diarmuid P, O'Sullivan, Jacintha, Geraghty, Robert, Sheahan, Kieran
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - pathology; Aged; Aged, 80 and over; Biological and medical sciences; Colonic Neoplasms - pathology; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Neoplasm Staging; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; peritoneal involvement; Peritoneum - pathology; prognosis; Stage II colonic carcinoma; tumour budding
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/j.1365-2559.2012.04250.x

Canney A L, Kevans D, Wang L M, Hyland J M P, Mulcahy H E, O’Donoghue D P, O’Sullivan J, Geraghty R & Sheahan K 
(2012) Histopathology 61, 488–496 Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding Aims:  Evaluation of peritoneal involvement in colonic cancer (CC) can be difficult. We studied pT4N0 cancers and their association with pathological prognostic markers, including tumour budding. Method and results:  Tumours were classified as (i) at the peritoneal surface or free in the peritoneal cavity (pT4a subgroup n = 44); (ii) directly invading adjacent organ (pT4b subgroup n = 8); or (iii) showing inflammatory involvement of the peritoneum (pT4I subgroup n = 25). A published pT3N0 cohort was used to compare Stage II subgroups. Standard pathological markers including tumour budding were assessed. Elastin staining was performed in the pT4I subgroup. Seventy‐seven Stage II CCs met inclusion criteria. There was no significant difference in survival across subgroups. pT4b tumours were larger than pT4a tumours (P