Autoantibodies in lupus: Culprits or passive bystanders?

Abstract Several autoantibodies are culprits in the pathogenesis of organ damage in systemic lupus erythematosus, by means of established or postulated mechanisms, whereby inducing a perturbation of cell structure and function, with consequent tissue–organ impairment. Common autoantibody-mediated me...

Full description

Saved in:
Bibliographic Details
Published in:Autoimmunity reviews 2012-06, Vol.11 (8), p.596-603
Main Authors: Rekvig, Ole P, Putterman, Chaim, Casu, Cinzia, Gao, Hua-Xin, Ghirardello, Anna, Mortensen, Elin S, Tincani, Angela, Doria, Andrea
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoantibodies
Cytology
Lupus nephritis
Neuropsychiatric SLE
Pathogenesis
Systemic lupus erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Several autoantibodies are culprits in the pathogenesis of organ damage in systemic lupus erythematosus, by means of established or postulated mechanisms, whereby inducing a perturbation of cell structure and function, with consequent tissue–organ impairment. Common autoantibody-mediated mechanisms of damage include cell surface binding with or without cytolysis, immune complex-mediated damage, penetration into living cells, binding to cross-reactive extracellular molecules. Experimental data from both murine models and humans have recently clarified the key role of autoantibodies in severe organ involvements, including nephritis, neuropsychiatric (NP) dysfunction, and cerebrovascular disease (CVD). In lupus nephritis early and late phases are distinguishable and mediated by different processes in which anti-chromatin antibodies are both inducing and perpetuating agents, by immune-complex formation and massive deposition in mesangial matrix at first, and in glomerular basement membrane at end-stage. Also NP abnormalities occur very early, much earlier than other systemic manifestations, and exacerbate with the increase in autoantibody titers. Among the autoantibodies mainly implicated in neurolupus, anti-β2 glycoprotein I (β2GPI) antibodies are preferentially involved in focal NP events which are a consequence of non-inflammatory microangiopathy; otherwise, anti-ribosomal P protein antibodies and N-methyl- d -aspartate receptor (NMDAR) antibodies cause diffuse NP events through a direct cytotoxic effect on neuronal cells at specific brain zones.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2011.10.021