Octopamine, unlike other trace amines, inhibits responses of astroglia-enriched cultures to lipopolysaccharide via a I2-adrenoreceptor-mediated mechanism

Trace amines (TAs), i.e. I2-phenylethylamine, tyramine and octopamine, are generally regarded as sympathomimetic compounds with structural and functional analogy with catecholamines. Previous reports have shown particularly high levels of circulating TAs in migraine and cluster headache patients. Ho...

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Bibliographic Details
Published in:Neuroscience letters 2012-05, Vol.517 (1), p.36-40
Main Authors: DaAndrea, Giovanni, DaArrigo, Antonello, Facchinetti, Fabrizio, Del Giudice, Elda, Colavito, Davide, Bernardini, Daniele, Leon, Alberta
Format: Article
Language:English
Subjects:
amines
Antagonists
Astrocytes
Catecholamines
Cell culture
Data processing
Headache
Lipopolysaccharides
Migraine
Nervous system
Neuromodulation
Nitric oxide
octopamine
Structure-function relationships
Sympathomimetics
tyramine
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Summary:Trace amines (TAs), i.e. I2-phenylethylamine, tyramine and octopamine, are generally regarded as sympathomimetic compounds with structural and functional analogy with catecholamines. Previous reports have shown particularly high levels of circulating TAs in migraine and cluster headache patients. However, no clues are yet available as to the pathophysiological significance of these alterations. The effect of different TAs on the release of nitric oxide was investigated in rat astroglial cells stimulated with lipopolysaccharide (LPS). Octopamine substantially inhibited the release of NO evoked by LPS. Tyramine and I2-PEA were ineffective. The inhibitory effect of octopamine was fully reverted by two selective antagonists of I2-adrenergic receptors, while [alpha]-adrenergic blockade was ineffective. These data, consistent with a role of octopamine as a modulator of NO release, uncover an interaction between octopamine and I2-adrenergic receptors in astroglial cells. These results may have an impact in understanding the mechanisms underlying migraine pathophysiology.
ISSN:0304-3940
DOI:10.1016/j.neulet.2012.04.013