Efficacy of platelet-rich plasma combined with allograft bone in the management of displaced intra-articular calcaneal fractures: A prospective cohort study

To investigate whether platelet‐rich plasma (PRP) when used with allograft bone improves the management outcome of displaced intra‐articular calcaneal fractures. Over a 7‐year period, all displaced type III calcaneal fractures admitted in our department (276 fractures in 254 patients) were randomly...

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Bibliographic Details
Published in:Journal of orthopaedic research 2012-10, Vol.30 (10), p.1570-1576
Main Authors: Wei, Li-Cheng, Lei, Guang-Hua, Sheng, Pu-yi, Gao, Shu-Guang, Xu, Mai, Jiang, Wei, Song, Yang, Luo, Wei
Format: Article
Language:English
Subjects:
Adolescent
Adult
allograft bone
Bone Transplantation
calcaneum fracture
Calcaneus - injuries
Female
Fracture Healing
Humans
Intra-Articular Fractures - therapy
Male
Middle Aged
Platelet-Rich Plasma
platelet-rich plasma (PRP)
Prospective Studies
Recovery of Function
Young Adult
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Summary:To investigate whether platelet‐rich plasma (PRP) when used with allograft bone improves the management outcome of displaced intra‐articular calcaneal fractures. Over a 7‐year period, all displaced type III calcaneal fractures admitted in our department (276 fractures in 254 patients) were randomly divided into three groups according to the plan of management: autograft alone (n = 101), allograft combined with PRP (n = 85), or allograft alone (n = 90). Radiographic imaging and three‐dimensional computed tomography were used to assess the thalamic portion, Bohler's angle, the crucial angle of Gissane, and the height, width and length of the calcaneum. The American Orthopedic Foot and Ankle Society (AOFAS) ankle‐hind‐foot scoring system was used to evaluate the hind foot function at 12, 24, and 72 months postsurgery. At 12 months no significant difference existed in outcome amongst the treatment groups (p > 0.05). However, at 24 and 72 months the results of the autograft, and the allograft combined with PRP, were similar and both were significantly better than that of the allograft alone (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.22118