Secondary Causes of Dyslipidemia

The causes of the lipid disorders in patients referred to specialty clinics for difficult-to-treat dyslipidemias are likely multifactorial. However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of...

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Bibliographic Details
Published in:The American journal of cardiology 2012-09, Vol.110 (6), p.823-825
Main Authors: Vodnala, Deepthi, MD, Rubenfire, Melvyn, MD, Brook, Robert D., MD
Format: Article
Language:English
Subjects:
Alcohol use
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cholesterol
Colleges & universities
Diet
Dyslipidemias - epidemiology
Dyslipidemias - etiology
Female
Humans
Hypothyroidism
Lipids
Lipoproteins
Male
Medical sciences
Middle Aged
Physicians
Prevalence
Retrospective Studies
Risk Factors
Triglycerides
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Summary:The causes of the lipid disorders in patients referred to specialty clinics for difficult-to-treat dyslipidemias are likely multifactorial. However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of Michigan Lipid Clinic from January 2004 to June 2011 (n = 824) to evaluate for the prevalence of several secondary causes of dyslipidemia. In addition to lipoproteins, new patients were assessed for secondary dyslipidemias by a standardized protocol consisting of laboratory testing, a nutritional evaluation, and medical history. These data were evaluated to determine the prevalence of several secondary causes of dyslipidemia. A total of 363 separate factors were identified in the 824 patients that were thought to be potential secondary causes of dyslipidemia. Because some patients (n = 83 [10%]) had multiple conditions, there were 230 (28% of the cohort) with ≥1 potential secondary dyslipidemias. The most common conditions were excessive alcohol intake (n = 82 [10%]), uncontrolled diabetes mellitus (n = 68 [8%]), and overt albuminuria. Although other causes occurred less frequently (each individually found in
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2012.04.062