Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: a possible preventive role for antioxidants

• Published in: European journal of clinical nutrition 2012-09, Vol.66 (9), p.1054-1058
• Main Authors: Neyestani, T R, Ghandchi, Z, Eshraghian, M-R, Kalayi, A, Shariatzadeh, N, Houshiarrad, A
• Format: Article
• Language: English
• Subjects: 692/53; 692/699/2743/137/1418; 692/700/459/1994; Adolescent; Adult; Antioxidants; Biological and medical sciences; Biomarkers; Blood; Blood Glucose - metabolism; Brothers and sisters; Case studies; Case-Control Studies; Child; Child, Preschool; Clinical Nutrition; Development and progression; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - enzymology; Diabetes Mellitus, Type 1 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Energy intake; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Genetic aspects; Glutathione; Glutathione - blood; Glutathione peroxidase; Glutathione Peroxidase - blood; Health aspects; Humans; Internal Medicine; Iran; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; original-article; Oxidative stress; Oxidative Stress - physiology; Peroxidase; Prevention; Public Health; Siblings; Statistics, Nonparametric; Superoxide dismutase; Superoxide Dismutase - blood; Type 1 diabetes; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2012.81

BACKGROUND/OBJECTIVES: Oxidative stress (OS) is thought to be involved in both development of type 1 diabetes (T1D) and its further complications. In this study, certain biomarkers of OS were compared among the subjects with T1D, their non-diabetic siblings and unrelated healthy controls. SUBJECTS/METHODS: Known cases of T1D from both sexes aged 5–25 years were enrolled in a case–control study ( n 1 =60). There were two control groups; non-diabetic siblings ( n 2 =60) and unrelated apparently healthy subjects ( n 3 =60). Anthropometric, dietary and laboratory assessments were done. RESULTS: There was no significant difference in dietary data among the groups. Total antioxidant capacity was significantly lower in T1D than both related and unrelated controls (1.6±0.05, 1.7±0.05 and 1.8±0.06 mmol BSA equivalent/l, respectively, P =0.044). Both T1D subjects and their siblings showed lower glutathione peroxidase (GSH-px) levels (median (interquartile range): 22.2 (28.6), 29.9 (23) and 41.8 (73.6) U/ml, respectively, P =0.006). On the contrary, superoxide dismutase concentrations were significantly higher in T1D group and the siblings than unrelated healthy controls (243 (45.3), 157.8 (176.9) and 27.9 (8.7) U/l, respectively, P