The bacterial signalling molecule indole attenuates the virulence of the fungal pathogen Candida albicans

Aims Indole is a signalling molecule, produced by a number of Gram‐positive and Gram‐negative bacteria both in nature as well as clinical environments. Here, we explored the effect of bacterial indole and one of its main derivatives on the virulence of the fungal pathogen Candida albicans. Methods a...

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Bibliographic Details
Published in:Journal of applied microbiology 2012-09, Vol.113 (3), p.622-628
Main Authors: Oh, S., Go, G.W., Mylonakis, E., Kim, Y.
Format: Article
Language:English
Subjects:
Animals
Bacteria
biofilms
Biofilms - drug effects
Biological and medical sciences
C. albicans
C. elegans
Caenorhabditis elegans
Caenorhabditis elegans - microbiology
Candida albicans
Candida albicans - drug effects
Candida albicans - pathogenicity
Fundamental and applied biological sciences. Psychology
HT29 Cells
Humans
indole signalling
Indoles - pharmacology
Microbiology
Nematoda
Pathology
Transcription Factors - metabolism
Virulence
Virulence Factors - metabolism
Yeast
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Summary:Aims Indole is a signalling molecule, produced by a number of Gram‐positive and Gram‐negative bacteria both in nature as well as clinical environments. Here, we explored the effect of bacterial indole and one of its main derivatives on the virulence of the fungal pathogen Candida albicans. Methods and Results We found that indole and its derivate indole‐3‐acetonitrile (IAN) did not affect the viability of C. albicans. Interestingly, indole and IAN repressed C. albicans biofilm formation as well as the attachment of C. albicans to intestinal epithelial HT‐29 cells and inhibited the ability of the yeast to make filaments that are the main virulence factor of C. albicans. In addition, we used the heterologous model host Caenorhabditis elegans to demonstrate in vivo that the presence of indole or IAN attenuates C. albicans infection (P = 0·0188 and P 
ISSN:1364-5072
1365-2672
DOI:10.1111/j.1365-2672.2012.05372.x