Tumor-specific MAGE proteins as regulators of p53 function

Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms cont...

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Bibliographic Details
Published in:Cancer letters 2012-12, Vol.325 (1), p.11-17
Main Authors: Ladelfa, María Fátima, Peche, Leticia Yamila, Toledo, María Fernanda, Laiseca, Julieta Eva, Schneider, Claudio, Monte, Martín
Format: Article
Language:English
Subjects:
Animals
Anticancer therapies
Antigen (tumor-associated)
antigens
Apoptosis
Cancer
Cell adhesion & migration
Cell growth
Cell Growth Processes - physiology
Cell proliferation
Data processing
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Epigenetics
Gene expression
genes
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
MAGE
Melanoma
Melanoma - genetics
Melanoma - metabolism
Melanoma-Specific Antigens - genetics
Melanoma-Specific Antigens - metabolism
p53
p53 protein
Proteins
Scholarships & fellowships
Transcription factors
Transcriptional inhibition
Tumor suppressor genes
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumors
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Description
Summary:Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.05.031