Black yeast-like fungi associated with Lethargic Crab Disease (LCD) in the mangrove-land crab, Ucides cordatus (Ocypodidae)

Lethargic Crab Disease (LCD) caused extensive epizootic mortality of the mangrove land crab Ucides cordatus (Brachyura: Ocypodidae) along the Brazilian coast, mainly in the Northeastern region. The disease was named after the symptoms of slow movement of infected crabs. Causative agents were suspect...

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Bibliographic Details
Published in:Veterinary microbiology 2012-07, Vol.158 (1-2), p.109-122
Main Authors: Vicente, Vania A., Orélis-Ribeiro, R., Najafzadeh, M.J., Sun, Jiufeng, Guerra, Raquel Schier, Miesch, Stephanie, Ostrensky, Antonio, Meis, Jacques F., Klaassen, Corné H., de Hoog, G.S., Boeger, Walter A.
Format: Article
Language:English
Subjects:
Amplified Fragment Length Polymorphism Analysis
Animals
Ascomycetes
Ascomycota - classification
Ascomycota - genetics
Ascomycota - isolation & purification
Ascomycota - pathogenicity
Biological and medical sciences
Brachyura
Brachyura - genetics
Brachyura - microbiology
Brazil
Chaetothyriales
Cladophialophora
Decapoda
Exophiala
Exophiala - classification
Exophiala - genetics
Exophiala - isolation & purification
Exophiala - pathogenicity
Exophiala cancerae
Fonsecaea
Fonsecaea brasiliensis
Fundamental and applied biological sciences. Psychology
Herpotrichiellaceae
Lethargic Crab Disease (LCD)
Mangrove crab
Microbiology
Miscellaneous
Multilocus Sequence Typing
Mycology
Ocypodidae
Phylogeny
Ucides cordatus
Virulence
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Summary:Lethargic Crab Disease (LCD) caused extensive epizootic mortality of the mangrove land crab Ucides cordatus (Brachyura: Ocypodidae) along the Brazilian coast, mainly in the Northeastern region. The disease was named after the symptoms of slow movement of infected crabs. Causative agents were suspected to be two black yeast-like fungi of the family Herpotrichiellaceae (ascomycete order Chaetothyriales), judged by infected tissue biopsies from moribund U. cordatus. The aim of the present study is to prove that two species are involved in the disease: the recently described black yeast Exophiala cancerae, but also a less virulent, hitherto undescribed fonsecaea-like species, introduced here as the novel species Fonsecaea brasiliensis. Strains were identified by ITS rDNA sequencing, and species borderlines were established by multilocus sequencing and AFLP analysis. Fonsecaea brasiliensis proved to be closely related to the pathogenic species Cladophialophora devriesii which originally was isolated from a systemic infection in a human patient. The virulence of F. brasiliensis is lower than that of E. cancerae, as established by artificial inoculation of mangrove crabs.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2012.01.031