Caffeine and risk of Parkinson's disease in a large cohort of men and women

Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD inci...

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Bibliographic Details
Published in:Movement disorders 2012-09, Vol.27 (10), p.1276-1282
Main Authors: Palacios, Natalia, Gao, Xiang, McCullough, Marjorie L., Schwarzschild, Michael A., Shah, Roma, Gapstur, Susan, Ascherio, Alberto
Format: Article
Language:English
Subjects:
Beverages
Biological and medical sciences
caffeine
Caffeine - metabolism
Caffeine - therapeutic use
Central Nervous System Stimulants - therapeutic use
coffee
Coffee - metabolism
Cohort Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
epidemiology
Female
Humans
Incidence
Male
Medical sciences
Movement disorders
Neurology
Nutritional Status
Parkinson
Parkinson Disease - epidemiology
Parkinson Disease - prevention & control
Proportional Hazards Models
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Characteristics
Surveys and Questionnaires
tea
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Summary:Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD incidence in the Cancer Prevention Study II Nutrition Cohort (CPS II–Nutrition), a large, prospective study of men and women. We conducted a prospective study of caffeine intake and risk of PD within the CPS II Nutrition Cohort. Intakes of coffee and other sources of caffeine were assessed at baseline. Incident cases of PD (n = 317; 197 men and 120 women) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and alcohol consumption. After adjustment for age, smoking, and alcohol intake, high caffeine consumption was associated with a reduced risk of PD. The RR comparing the 5th to the 1st quintile of caffeine intake was 0.43 (95% confidence interval [CI]: 0.26, 0.71; P trend =
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.25076