Non-invasive diagnosis of lung tuberculosis in children by single voxel super(1)H-magnetic resonance spectroscopy

Our previous study showed that super(1)H-magnetic resonance spectroscopy ( super(1)H-MRS) can detect lipid peaks characteristic for Mycobacterium tuberculosis infection in cerebral lesions of young children; therefore, we aimed to extend and validate the application of super(1)H-MRS for the diagnosi...

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Bibliographic Details
Published in:European journal of pediatrics 2012-08, Vol.171 (8), p.1257-1263
Main Authors: Santy, Ky, Nan, Phang, Chantana, Yay, Laurent, Denis, Scheer, Ianina, Steinmann, Beat, Nadal, David, Richner, Beat
Format: Article
Language:English
Subjects:
Abscesses
Adolescence
Bacilli
Cavities
Central nervous system
Children
Genetic screening
Infection
Lipids
Lung
Microscopy
Mycobacterium tuberculosis
Pleural effusion
Spectroscopy
Sputum
Tuberculosis
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Summary:Our previous study showed that super(1)H-magnetic resonance spectroscopy ( super(1)H-MRS) can detect lipid peaks characteristic for Mycobacterium tuberculosis infection in cerebral lesions of young children; therefore, we aimed to extend and validate the application of super(1)H-MRS for the diagnosis of active pulmonary tuberculosis lesions in three adolescent patients. Here, we document lipid peaks characteristic for M. tuberculosis infection by super(1)H-MRS from lung tissue surrounding lung cavities of two patients whose sputum samples were positive for acid-fast bacilli by microscopy and positive for M. tuberculosis by genetic testing, indicating active tuberculosis. A similar lipid peak was found also in the pleural effusion of a third patient with concurrent lung cavity compatible with active tuberculosis. However, in a patient with a pyogenic pulmonary abscess, super(1)H-MRS of the drained pus displayed different characteristic peaks but no lipid peak at all. Conclusion: Our findings further validate super(1)H-MRS as a rapid, non-invasive, and specific diagnostic tool for active tuberculosis in children with microbiologically documented infection outside the central nervous system, specifically in the lungs.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-012-1768-7