Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare

Aim of the study: This study aimed to assess correlation of urinary monocytic chemoattractant protein-1 (UMCP-1) with severity of lupus nephritis and its role as predictor of outcome. Method: Twenty patients with lupus nephritis flare were included in the study. Ten patients in each group of stable...

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Bibliographic Details
Published in:Lupus 2012-10, Vol.21 (11), p.1214-1218
Main Authors: Singh, RG, Usha, Rathore, SS, Behura, SK, Singh, NK
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - urine
Biopsy
Chemokine CCL2 - urine
Chemotactic factors
Creatinine
Creatinine - metabolism
Female
Follow-Up Studies
Humans
Lupus
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - therapy
Lupus Erythematosus, Systemic - urine
Lupus nephritis
Lupus Nephritis - diagnosis
Lupus Nephritis - therapy
Lupus Nephritis - urine
Male
Monocyte chemoattractant protein 1
Monocytes
Nephrology
Patients
Prognosis
Proteins
Remission
Remission (Medicine)
Remission Induction
Severity of Illness Index
Systemic lupus erythematosus
Treatment Outcome
Urine
Young Adult
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Summary:Aim of the study: This study aimed to assess correlation of urinary monocytic chemoattractant protein-1 (UMCP-1) with severity of lupus nephritis and its role as predictor of outcome. Method: Twenty patients with lupus nephritis flare were included in the study. Ten patients in each group of stable systemic lupus erythematosus and non-renal flare were taken as controls. Biopsy was done to define lupus nephritis stage. UMCP-1 levels were measured in all patients at the time of entry and at four and eight weeks of follow-up. Results: Mild, moderate and severe lupus nephritis flare was noted in one, five and 15 patients, respectively. UMCP-1 levels were high in patients with severe lupus nephritis flare (2.74 ± 0.95 ng/mg creatinine) as compared to patients with moderate (1.43 ± 0.46 ng/mg creatinine) and mild lupus nephritis flare (0.76 ± 0.57 ng/mg creatinine) (P = 0.0093). Baseline mean UMCP-1 levels in lupus nephritis flare, non-renal flare and stable SLE patients were 2.32 ± 1.06, 0.171 ± 0.03 and 0.213 ± 0.026 ng/mg creatinine, respectively. The difference among the three groups was very significant (P 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203312452622