Multiple subcortical acute ischemic lesions reflect small vessel disease rather than cardiogenic embolism

Multiple acute ischemic lesions in different hemispheres or vascular territories are mainly considered to be of proximal embolic origin. However, despite careful diagnostic work-up, the etiological classification often stays undetermined. We propose that multiple acute ischemic lesions can sometimes...

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Bibliographic Details
Published in:Journal of neurology 2012-09, Vol.259 (9), p.1951-1957
Main Authors: Wolf, M. E., Sauer, T., Kern, R., Szabo, K., Hennerici, M. G.
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Biological and medical sciences
Blood Vessels - pathology
Brain Ischemia - complications
Brain Ischemia - etiology
Cerebral infarction
Cerebral Infarction - etiology
Classification
Diffusion Magnetic Resonance Imaging
Embolism
Embolism - complications
Embolisms
Etiology
Female
Follow-Up Studies
Humans
Ischemia
Magnetic Resonance Imaging
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Neuroradiology
Neurosciences
Original Communication
Patients
Prospective Studies
Risk Factors
Stroke
Territory
Ultrasonic imaging
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Summary:Multiple acute ischemic lesions in different hemispheres or vascular territories are mainly considered to be of proximal embolic origin. However, despite careful diagnostic work-up, the etiological classification often stays undetermined. We propose that multiple acute ischemic lesions can sometimes be a phenomenon observed in small vessel disease (SVD). From a prospectively collected database of more than 7,000 stroke patients, 173 patients with acute bihemispheric infarction were identified. We analyzed those subjects with multiple small (
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-012-6451-4