Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression

► Sigma1 ligand treatment mediates decrease in tumor cell mass. ► Identification of a Sigma1 ligand with reversible translational repressor actions. ► Demonstration of a role for Sigma1 in cellular protein synthesis. Treatment with sigma1 receptor (Sigma1) ligands can inhibit cell proliferation in v...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications 2012-09, Vol.426 (2), p.177-182
Main Authors:	Kim, Felix J., Schrock, Joel M., Spino, Christina M., Marino, Jacqueline C., Pasternak, Gavril W.
Format:	Article
Language:	English
Subjects:	60 APPLIED LIFE SCIENCES antagonists cell growth Cell Line, Tumor Cell mass CELL PROLIFERATION Cell Proliferation - drug effects Cell Size - drug effects Haloperidol - pharmacology Humans IN VITRO IN VIVO INHIBITION LIGANDS MAMMARY GLANDS Morpholines - pharmacology neoplasm cells NEOPLASMS Neoplasms - metabolism Neoplasms - pathology Phenazocine - analogs & derivatives Phenazocine - pharmacology PHOSPHORYLATION PROSTATE prostatic neoplasms Protein Biosynthesis - drug effects protein synthesis Protein translation proteins RECEPTORS Receptors, sigma - antagonists & inhibitors RNA Cap-Binding Proteins - metabolism Sigma-1 Receptor Sigma1 ligand Sigma1 receptor translation (genetics) Tumor TUMOR CELLS
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