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Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis
Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effectiv...
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| Published in: | Circulation Journal 2012, Vol.76(10), pp.2380-2385 |
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| container_end_page | 2385 |
| container_issue | 10 |
| container_start_page | 2380 |
| container_title | Circulation Journal |
| container_volume | 76 |
| creator | Hung, Kuo-Chun Lee, Cheng-Hung Chen, Chun-Chi Chu, Chi-Ming Wang, Chao-Yung Hsieh, I-Chang Fang, Ji-Tseng Lin, Fen-Chiung Wen, Ming-Shien |
| description | Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effective means of quantifying myocardial diastolic function, its differences in ESRD patients with diabetes and without diabetes remain unclear. Methods and Results: A total of 101 ESRD patients on maintenance hemodialysis with normal LV systolic function were studied: 37 with type 2 DM and 64 without DM. Conventional echocardiography and TDI were performed to evaluate LV systolic and diastolic functions. The conventional LV systolic and diastolic echocardiographic parameters did not differ according to presence of DM, except for the left atrial size and volume index (P |
| doi_str_mv | 10.1253/circj.CJ-12-0471 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1080655155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1080655155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-d74cdd9ae94da6397a4e90b6d80a73b2da4f407483cc740daa887e81d00b16d73</originalsourceid><addsrcrecordid>eNpFkEtP3DAURi1UxKvds6q87CZgJ07sLNFQXhoEC2iX0Y19Ax4lztR2Ks2_x2EG2Pja1vnOlT5CTjk743lZnGvr9epscZfxPGNC8j1yxAshM6Fy9u39XmW1EsUhOQ5hxVhes7I-IId5LlUlJDsi4cL8B6fR0CV2kf5BF73VUw-eXloIceytppeb0E1ORzs6ah199jik30eINuGB_rXxlT5t1kjzOdRixEATeg_WRXSznt7gMBoL_SbY8J3sd9AH_LGbJ-T56vfT4iZbPlzfLi6WmRZ1GTMjhTamBqyFgaqoJQisWVsZxUAWbW5AdIJJoQqtpWAGQCmJihvGWl4ZWZyQX1vv2o__JgyxGWzQ2PfgcJxCw5liVVnyskwo26LajyF47Jq1twP4TYKauermvepmcZdezVx1ivzc2ad2QPMZ-Og2AddbYBUivOAnAD5a3ePOKKt5RTq_1F_EK_gGXfEGRyKV7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1080655155</pqid></control><display><type>article</type><title>Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis</title><source>Freely Accessible Medical Journals</source><creator>Hung, Kuo-Chun ; Lee, Cheng-Hung ; Chen, Chun-Chi ; Chu, Chi-Ming ; Wang, Chao-Yung ; Hsieh, I-Chang ; Fang, Ji-Tseng ; Lin, Fen-Chiung ; Wen, Ming-Shien</creator><creatorcontrib>Hung, Kuo-Chun ; Lee, Cheng-Hung ; Chen, Chun-Chi ; Chu, Chi-Ming ; Wang, Chao-Yung ; Hsieh, I-Chang ; Fang, Ji-Tseng ; Lin, Fen-Chiung ; Wen, Ming-Shien</creatorcontrib><description>Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effective means of quantifying myocardial diastolic function, its differences in ESRD patients with diabetes and without diabetes remain unclear. Methods and Results: A total of 101 ESRD patients on maintenance hemodialysis with normal LV systolic function were studied: 37 with type 2 DM and 64 without DM. Conventional echocardiography and TDI were performed to evaluate LV systolic and diastolic functions. The conventional LV systolic and diastolic echocardiographic parameters did not differ according to presence of DM, except for the left atrial size and volume index (P<0.001). The ESRD patients with DM, however, had significantly decreased mitral annular early diastolic peak velocity (e’) and ratio of early to late diastolic mitral annular velocity (e’/a’; both P<0.02). Additionally, the group with DM had markedly higher estimated LV end-diastolic filling pressure (E/e’; P=0.011). Conclusions: ESRD patients with DM had advanced LV diastolic dysfunction on TDI. In ESRD patients with DM, diabetic cardiomyopathy associated with advanced LV diastolic dysfunction is observed. (Circ J 2012; 76: 2380–2385)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-12-0471</identifier><identifier>PMID: 22786470</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adult ; Aged ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - diagnostic imaging ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - therapy ; Diabetic Nephropathies - diagnostic imaging ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - therapy ; Diastole ; Echocardiography, Doppler ; End-stage renal disease ; Female ; Heart Atria - diagnostic imaging ; Heart Atria - physiopathology ; Humans ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Male ; Middle Aged ; Renal Dialysis ; Tissue Doppler imaging ; Uremia - diagnostic imaging ; Uremia - etiology ; Uremia - physiopathology ; Uremia - therapy ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Dysfunction, Left - therapy</subject><ispartof>Circulation Journal, 2012, Vol.76(10), pp.2380-2385</ispartof><rights>2012 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-d74cdd9ae94da6397a4e90b6d80a73b2da4f407483cc740daa887e81d00b16d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22786470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hung, Kuo-Chun</creatorcontrib><creatorcontrib>Lee, Cheng-Hung</creatorcontrib><creatorcontrib>Chen, Chun-Chi</creatorcontrib><creatorcontrib>Chu, Chi-Ming</creatorcontrib><creatorcontrib>Wang, Chao-Yung</creatorcontrib><creatorcontrib>Hsieh, I-Chang</creatorcontrib><creatorcontrib>Fang, Ji-Tseng</creatorcontrib><creatorcontrib>Lin, Fen-Chiung</creatorcontrib><creatorcontrib>Wen, Ming-Shien</creatorcontrib><title>Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effective means of quantifying myocardial diastolic function, its differences in ESRD patients with diabetes and without diabetes remain unclear. Methods and Results: A total of 101 ESRD patients on maintenance hemodialysis with normal LV systolic function were studied: 37 with type 2 DM and 64 without DM. Conventional echocardiography and TDI were performed to evaluate LV systolic and diastolic functions. The conventional LV systolic and diastolic echocardiographic parameters did not differ according to presence of DM, except for the left atrial size and volume index (P<0.001). The ESRD patients with DM, however, had significantly decreased mitral annular early diastolic peak velocity (e’) and ratio of early to late diastolic mitral annular velocity (e’/a’; both P<0.02). Additionally, the group with DM had markedly higher estimated LV end-diastolic filling pressure (E/e’; P=0.011). Conclusions: ESRD patients with DM had advanced LV diastolic dysfunction on TDI. In ESRD patients with DM, diabetic cardiomyopathy associated with advanced LV diastolic dysfunction is observed. (Circ J 2012; 76: 2380–2385)</description><subject>Adult</subject><subject>Aged</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - diagnostic imaging</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetic Nephropathies - diagnostic imaging</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Diastole</subject><subject>Echocardiography, Doppler</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Atria - physiopathology</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis</subject><subject>Tissue Doppler imaging</subject><subject>Uremia - diagnostic imaging</subject><subject>Uremia - etiology</subject><subject>Uremia - physiopathology</subject><subject>Uremia - therapy</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Dysfunction, Left - therapy</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpFkEtP3DAURi1UxKvds6q87CZgJ07sLNFQXhoEC2iX0Y19Ax4lztR2Ks2_x2EG2Pja1vnOlT5CTjk743lZnGvr9epscZfxPGNC8j1yxAshM6Fy9u39XmW1EsUhOQ5hxVhes7I-IId5LlUlJDsi4cL8B6fR0CV2kf5BF73VUw-eXloIceytppeb0E1ORzs6ah199jik30eINuGB_rXxlT5t1kjzOdRixEATeg_WRXSznt7gMBoL_SbY8J3sd9AH_LGbJ-T56vfT4iZbPlzfLi6WmRZ1GTMjhTamBqyFgaqoJQisWVsZxUAWbW5AdIJJoQqtpWAGQCmJihvGWl4ZWZyQX1vv2o__JgyxGWzQ2PfgcJxCw5liVVnyskwo26LajyF47Jq1twP4TYKauermvepmcZdezVx1ivzc2ad2QPMZ-Og2AddbYBUivOAnAD5a3ePOKKt5RTq_1F_EK_gGXfEGRyKV7w</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Hung, Kuo-Chun</creator><creator>Lee, Cheng-Hung</creator><creator>Chen, Chun-Chi</creator><creator>Chu, Chi-Ming</creator><creator>Wang, Chao-Yung</creator><creator>Hsieh, I-Chang</creator><creator>Fang, Ji-Tseng</creator><creator>Lin, Fen-Chiung</creator><creator>Wen, Ming-Shien</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis</title><author>Hung, Kuo-Chun ; Lee, Cheng-Hung ; Chen, Chun-Chi ; Chu, Chi-Ming ; Wang, Chao-Yung ; Hsieh, I-Chang ; Fang, Ji-Tseng ; Lin, Fen-Chiung ; Wen, Ming-Shien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-d74cdd9ae94da6397a4e90b6d80a73b2da4f407483cc740daa887e81d00b16d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - diagnostic imaging</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetic Nephropathies - diagnostic imaging</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Diastole</topic><topic>Echocardiography, Doppler</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Atria - physiopathology</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Dialysis</topic><topic>Tissue Doppler imaging</topic><topic>Uremia - diagnostic imaging</topic><topic>Uremia - etiology</topic><topic>Uremia - physiopathology</topic><topic>Uremia - therapy</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Dysfunction, Left - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hung, Kuo-Chun</creatorcontrib><creatorcontrib>Lee, Cheng-Hung</creatorcontrib><creatorcontrib>Chen, Chun-Chi</creatorcontrib><creatorcontrib>Chu, Chi-Ming</creatorcontrib><creatorcontrib>Wang, Chao-Yung</creatorcontrib><creatorcontrib>Hsieh, I-Chang</creatorcontrib><creatorcontrib>Fang, Ji-Tseng</creatorcontrib><creatorcontrib>Lin, Fen-Chiung</creatorcontrib><creatorcontrib>Wen, Ming-Shien</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hung, Kuo-Chun</au><au>Lee, Cheng-Hung</au><au>Chen, Chun-Chi</au><au>Chu, Chi-Ming</au><au>Wang, Chao-Yung</au><au>Hsieh, I-Chang</au><au>Fang, Ji-Tseng</au><au>Lin, Fen-Chiung</au><au>Wen, Ming-Shien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2012</date><risdate>2012</risdate><volume>76</volume><issue>10</issue><spage>2380</spage><epage>2385</epage><pages>2380-2385</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effective means of quantifying myocardial diastolic function, its differences in ESRD patients with diabetes and without diabetes remain unclear. Methods and Results: A total of 101 ESRD patients on maintenance hemodialysis with normal LV systolic function were studied: 37 with type 2 DM and 64 without DM. Conventional echocardiography and TDI were performed to evaluate LV systolic and diastolic functions. The conventional LV systolic and diastolic echocardiographic parameters did not differ according to presence of DM, except for the left atrial size and volume index (P<0.001). The ESRD patients with DM, however, had significantly decreased mitral annular early diastolic peak velocity (e’) and ratio of early to late diastolic mitral annular velocity (e’/a’; both P<0.02). Additionally, the group with DM had markedly higher estimated LV end-diastolic filling pressure (E/e’; P=0.011). Conclusions: ESRD patients with DM had advanced LV diastolic dysfunction on TDI. In ESRD patients with DM, diabetic cardiomyopathy associated with advanced LV diastolic dysfunction is observed. (Circ J 2012; 76: 2380–2385)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>22786470</pmid><doi>10.1253/circj.CJ-12-0471</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation Journal, 2012, Vol.76(10), pp.2380-2385 |
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| language | eng |
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| source | Freely Accessible Medical Journals |
| subjects | Adult Aged Diabetes mellitus Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Diabetic Nephropathies - diagnostic imaging Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Diastole Echocardiography, Doppler End-stage renal disease Female Heart Atria - diagnostic imaging Heart Atria - physiopathology Humans Kidney Failure, Chronic - etiology Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Middle Aged Renal Dialysis Tissue Doppler imaging Uremia - diagnostic imaging Uremia - etiology Uremia - physiopathology Uremia - therapy Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - therapy |
| title | Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis |
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