Oat β‑Glucan Increased ATPases Activity and Energy Charge in Small Intestine of Rats

• Published in: Journal of agricultural and food chemistry 2012-10, Vol.60 (39), p.9822-9827
• Main Authors: Zhang, Pei-Pei, Hu, Xin-Zhong, Zhen, Hong-Min, Xu, Chao, Fan, Ming-Tao
• Format: Article
• Language: English
• Subjects: Adenosine Triphosphatases - metabolism; Animals; Avena - metabolism; beta-glucans; beta-Glucans - metabolism; Bifidobacterium; Bifidobacterium - growth & development; Biological and medical sciences; cardiovascular diseases; Cereal and baking product industries; colon; Colon - microbiology; diet; Dietary Fiber - metabolism; Energy; Energy Metabolism; Food industries; Fundamental and applied biological sciences. Psychology; General aspects; Humans; ileum; insulin resistance; Intestine, Small - enzymology; Intestine, Small - metabolism; Intestine, Small - microbiology; Lactobacillus; Lactobacillus - growth & development; Male; oats; Rats; Rats, Sprague-Dawley; risk; Up-Regulation
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf3017496

Dietary oat or oat products may potentially help to fight against high risk of cardiovascular diseases and β-glucan in oat was considered as a central player. The present study aimed to investigate the effects of dietary oat whole meal or β-glucan on insulin sensitivity and energy metabolism of rats. Rats were fed with control diet, oat whole meal based diet, or control diet with supplemented β-glucan for 4 weeks. Oat whole meal and β-glucan increased insulin sensitivity index. Interestingly, supplementation of oat whole meal or β-glucan induced increases in intestinal Na+K+-ATPase activity, Ca2+Mg2+-ATPase activity, and energy charge, particularly in the distal part of small intestine (ileum). Furthermore, amounts of Bifidobacterium and Lactobacillus in colon contents were elevated by oat whole meal or β-glucan. These findings provide an insight into that β-glucan increased insulin sensitivity and benefited intestinal health.