Mechanical stress meets autophagy: potential implications for physiology and pathology

Changes in the mechanical environment are a universal challenge for cells, and mechanical cues regulate tissue structure and cell physiology throughout life. Autophagy is an important degradative pathway, fulfilling a wide range of roles in survival, homeostasis and adaptation. The two are connected...

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Bibliographic Details
Published in:Trends in molecular medicine 2012-10, Vol.18 (10), p.583-588
Main Author: King, Jason S
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Autophagy
Bone and Bones - chemistry
Heart - physiopathology
Homeostasis
Humans
mechanical stress
mechanotransduction
Models, Animal
Muscle, Skeletal - chemistry
Pathology
Signal Transduction
Stress, Mechanical
Stress, Physiological
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Summary:Changes in the mechanical environment are a universal challenge for cells, and mechanical cues regulate tissue structure and cell physiology throughout life. Autophagy is an important degradative pathway, fulfilling a wide range of roles in survival, homeostasis and adaptation. The two are connected, and in vitro , autophagy is rapidly induced in cells exposed to mechanical compression. In vivo , autophagy is also induced in several medically relevant circumstances that are also under mechanical stress such as bone and muscle homeostasis and tissue injury. The induction of autophagy has wide-ranging effects on cells. In this article, I propose that the autophagic response to mechanical stress is an important factor in a wide range of both physiological and pathological settings.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2012.08.002