Propofol improves recovery of the isolated working hypertrophic heart from ischaemia–reperfusion

The general anaesthetic propofol shows promise in protecting normal hearts against various cardiac insults, but little is known about its cardioprotective potential in hypertrophic hearts. This study tested the hypothesis that propofol at a clinically relevant dose would enhance functional recovery...

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Bibliographic Details
Published in:Pflügers Archiv 2012-11, Vol.464 (5), p.513-522
Main Authors: King, Nicola, Al Shaama, Madj, Suleiman, M.-Saadeh
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cardiac Output - drug effects
Cardiomegaly - physiopathology
Cell Biology
Human Physiology
In Vitro Techniques
Molecular Medicine
Myocardial Reperfusion
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
NAD - metabolism
Neurosciences
Organ Physiology
Propofol - pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors
Stroke Volume - drug effects
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Summary:The general anaesthetic propofol shows promise in protecting normal hearts against various cardiac insults, but little is known about its cardioprotective potential in hypertrophic hearts. This study tested the hypothesis that propofol at a clinically relevant dose would enhance functional recovery in hypertrophic hearts following ischaemia. Hypertrophic hearts from spontaneously hypertensive rats and hearts from their normotensive controls, Wistar Kyoto Rats, were equilibrated in the working mode prior to global normothermic ischaemia. Reperfusion commenced with 10 min in Langendorff mode, followed by 30-min working reperfusion. Functional performance was measured throughout the working mode, whilst reperfusion damage was assessed from myocardial troponin I release during Langendorff reperfusion. Where used, 4 μg/ml propofol was added 10 min before ischaemia and was washed out 10 min into working reperfusion. An additional protocol investigated recovery of hearts protected by normothermic hyperkalaemic cardioplegic arrest. Following 20-min ischaemia, reperfusion damage was significantly worse in hypertrophic hearts compared to normal hearts, whilst addition of propofol to hypertrophic hearts significantly improved the aortic flow (31 ± 5.8 vs. 11.6 ± 2.0 ml/min, n  = 6–7 ± SE, p  
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-012-1152-5