Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn’s disease activity: a preliminary study

Objective To compare quantified terminal ileal (TI) motility during MR enterography (MRE) with histopathological severity of acute inflammation in Crohn’s disease. Methods A total of 28 Crohn’s patients underwent MRE and endoscopic TI biopsy. Axial and coronal TrueFISP, HASTE and post-gadolinium VIB...

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Bibliographic Details
Published in:European radiology 2012-11, Vol.22 (11), p.2494-2501
Main Authors: Menys, Alex, Atkinson, David, Odille, Freddy, Ahmed, Asia, Novelli, Marco, Rodriguez-Justo, Manuel, Proctor, Ian, Punwani, Shonit, Halligan, Steve, Taylor, Stuart A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Algorithms
Biomarkers
Biomarkers - metabolism
Biopsy
Cohort Studies
Crohn Disease - diagnosis
Crohn Disease - metabolism
Crohn's disease
Diagnostic Imaging - methods
Diagnostic Radiology
Endoscopy
Endoscopy - methods
Female
Gastrointestinal
Gastrointestinal Motility
Humans
Imaging
Inflammation
Internal Medicine
Interventional Radiology
Intestines - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Motility
Neuroradiology
Patients
Radiology
Reproducibility of Results
Small intestine
Software
Ultrasound
University colleges
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Summary:Objective To compare quantified terminal ileal (TI) motility during MR enterography (MRE) with histopathological severity of acute inflammation in Crohn’s disease. Methods A total of 28 Crohn’s patients underwent MRE and endoscopic TI biopsy. Axial and coronal TrueFISP, HASTE and post-gadolinium VIBE images were supplemented by multiple coronal TrueFISP cine motility sequences through the small bowel volume. TI motility index (MI) was quantified using validated software; an acute inflammation score (eAIS; 0–6) was assigned to the biopsy. Two observers qualitatively scored mural thickness, T2 signal, contrast enhancement and perimural oedema (0–3) to produce an activity score (aMRIs) based on anatomical MRI. The association among the MI, eAIS and aMRIs was tested using Spearman’s rank correlation. Wilcoxon rank sum test compared motility in subjects with and without histopathological inflammation. Results Mean MI and mean eAIS were 0.27 (range 0.06–0.55) and 1.5 (range 0–5), respectively. There was a significant difference in MI between non-inflamed (mean 0.37, range 0.13–0.55) and inflamed (mean 0.19, range 0.06–0.44) TI, P  = 0.002, and a significant negative correlation between MI and both eAIS (Rho = −0.52, P  = 0.005) and aMRIs (R = −0.7, P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-012-2514-2