Twenty-Year Outcomes after Breast-Conserving Surgery and Definitive Radiotherapy for Mammographically Detected Ductal Carcinoma In Situ

Background Management of mammographically detected ductal carcinoma in situ (DCIS) at a single institution was reviewed to determine long-term clinical outcomes after treatment with breast-conserving therapy (BCT). Methods Data from all patient-cases with DCIS who received BCT between 1980 and 1993...

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Bibliographic Details
Published in:Annals of surgical oncology 2012-11, Vol.19 (12), p.3785-3791
Main Authors: Wilkinson, J. Ben, Vicini, Frank A., Shah, Chirag, Shaitelman, Simona, Jawad, Maha S., Ye, Hong, Kestin, Larry L., Goldstein, Neal S., Martinez, Alvaro A., Benitez, Pamela, Chen, Peter Y.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Breast Oncology
Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating - mortality
Carcinoma, Intraductal, Noninfiltrating - therapy
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Mammography
Mastectomy
Mastectomy, Segmental
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Oncology
Prognosis
Radiotherapy, Adjuvant
Risk Factors
Surgery
Surgical Oncology
Survival Rate
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Summary:Background Management of mammographically detected ductal carcinoma in situ (DCIS) at a single institution was reviewed to determine long-term clinical outcomes after treatment with breast-conserving therapy (BCT). Methods Data from all patient-cases with DCIS who received BCT between 1980 and 1993 were reviewed. Patient demographics and pathologic factors were analyzed for their effect on outcomes, including ipsilateral breast tumor recurrence (IBTR) and survival. BCT included breast-conserving surgery followed by external-beam radiotherapy to the whole breast, with 86 % of patients receiving a lumpectomy cavity boost. The median dose to the whole breast was 50 Gy and 60.4 Gy to the lumpectomy cavity. Results A total of 129 cases were evaluated; the median follow-up was 19.3 years. Twenty-one patients developed an ipsilateral breast tumor recurrence (IBTR), 76.2 % of which were invasive ( n  = 16). Fourteen recurrences (66 %) were within the same breast quadrant (true recurrence), while an additional 7 cases developed an IBTR elsewhere in the breast. True recurrences were more prevalent in women
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-012-2412-5