Frontiers of rapid itch relief: a review of methylprednisolone aceponate

In a paediatric population, the successful management of childhood atopic dermatitis (AD) should include the careful evaluation and selection of available therapies, based not only on demonstrated safety and tolerability in small children and infants, but also on their evidence‐based, anti‐pruritic...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2012-11, Vol.26 (s6), p.9-13
Main Authors: Ponte, L. García, Ebert, U.
Format: Article
Language:English
Subjects:
Adolescent
Anti-Inflammatory Agents - therapeutic use
Child
Child, Preschool
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - physiopathology
Humans
Infant
Methylprednisolone - analogs & derivatives
Methylprednisolone - therapeutic use
Pruritus - drug therapy
Pruritus - physiopathology
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Summary:In a paediatric population, the successful management of childhood atopic dermatitis (AD) should include the careful evaluation and selection of available therapies, based not only on demonstrated safety and tolerability in small children and infants, but also on their evidence‐based, anti‐pruritic benefits. Moreover, the speed of anti‐pruritic effect should be considered a significant parameter in treatment selection. The fourth‐generation topical corticosteroid (TC) methylprednisolone aceponate (MPA) is a potent anti‐inflammatory agent with a demonstrated fast and effective itch relief profile in children and infants (as young as 2 months) with AD. Compared with traditional TCs, MPA has a significantly improved therapeutic index; that is, increased potency without a proportionate increase in side effects. In addition to its established efficacy, the once‐daily application and broad range of available formulations make MPA an optimal choice for acute and maintenance therapy in paediatric patients with AD‐related pruritus.
ISSN:0926-9959
1468-3083
DOI:10.1111/j.1468-3083.2012.04711.x