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Tubercle bacilli rely on a type VII army for pathogenicity

Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secre...

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Published in:	Trends in microbiology (Regular ed.) 2012-10, Vol.20 (10), p.477-484
Main Authors:	Stoop, Esther J.M, Bitter, Wilbert, van der Sar, Astrid M
Format:	Article
Language:	English
Subjects:	Bacterial Proteins - secretion Bacterial Secretion Systems ESX granuloma formation Humans hydrophobicity Internal Medicine Models, Biological mycobacteria Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity pathogens protein secretion Protein Transport tuberculosis type VII secretion virulence Virulence Factors - metabolism
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description	Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.
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source	ScienceDirect Freedom Collection 2022-2024
subjects	Bacterial Proteins - secretion Bacterial Secretion Systems ESX granuloma formation Humans hydrophobicity Internal Medicine Models, Biological mycobacteria Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity pathogens protein secretion Protein Transport tuberculosis type VII secretion virulence Virulence Factors - metabolism
title	Tubercle bacilli rely on a type VII army for pathogenicity
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