Serum neurofilament concentrations in children with prolonged febrile seizures

Abstract Objective Neurofilament (NF) is a major cytoskeletal protein of neurons. Elevation of serum NF concentration suggests neuronal injury, especially damage to axons. We assessed neuronal damage in febrile seizure (FS) by using NF. Methods We used enzyme-linked immunosorbent assay to measure se...

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Bibliographic Details
Published in:Journal of the neurological sciences 2012-10, Vol.321 (1), p.39-42
Main Authors: Matsushige, Takeshi, Inoue, Hirofumi, Fukunaga, Shinnosuke, Hasegawa, Shunji, Okuda, Masayuki, Ichiyama, Takashi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Febrile seizure
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Indexing in process
Infant
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurofilament
Neurofilament Proteins - blood
Neurology
Prolonged febrile seizure
Seizure duration
Seizures, Febrile - blood
Serum
Simple febrile seizure
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Summary:Abstract Objective Neurofilament (NF) is a major cytoskeletal protein of neurons. Elevation of serum NF concentration suggests neuronal injury, especially damage to axons. We assessed neuronal damage in febrile seizure (FS) by using NF. Methods We used enzyme-linked immunosorbent assay to measure serum levels of the phosphorylated form of NF-heavy chain (pNF-H) in 42 children with FS and 28 controls. Results Serum pNF-H levels in children with prolonged febrile seizure (PFS) (n = 29) were significantly higher than those in the controls (p < 0.001). There were no significant differences in serum pNF-H levels between children with simple febrile seizure (n = 9) and the controls. There was a significant correlation between seizure duration and serum pNF-H levels during the first week in children with FS (p = 0.022, r = 0.37). Conclusion Our results suggest that PFS could lead to some degree of neuronal damage even in the absence of abnormal clinical neurological findings during the short-term follow up period.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2012.07.043