Switching iron-deficient whole blood donors to plateletpheresis

BACKGROUND: Iron deficiency is a frequent side effect of whole blood (WB) donation. In contrast, less red blood cell loss and therefore less iron loss results from plateletpheresis. STUDY DESIGN AND METHODS: WB donors presenting a decrease in either hemoglobin (Hb) or ferritin levels were offered to...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2012-10, Vol.52 (10), p.2183-2188
Main Authors: O'Meara, Alix, Infanti, Laura, Sigle, Jörg, Stern, Martin, Buser, Andreas
Format: Article
Language:English
Subjects:
Adult
Algorithms
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - drug therapy
Anemia, Iron-Deficiency - etiology
Anemia, Iron-Deficiency - prevention & control
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Appointments and Schedules
Biological and medical sciences
Blood Donors
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Bone marrow, stem cells transplantation. Graft versus host reaction
Female
Ferritins - blood
Ferrous Compounds - administration & dosage
Ferrous Compounds - therapeutic use
Hemoglobins - analysis
Humans
Iron - metabolism
Male
Medical sciences
Middle Aged
Phlebotomy - adverse effects
Platelet Count
Plateletpheresis - instrumentation
Plateletpheresis - methods
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Young Adult
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Summary:BACKGROUND: Iron deficiency is a frequent side effect of whole blood (WB) donation. In contrast, less red blood cell loss and therefore less iron loss results from plateletpheresis. STUDY DESIGN AND METHODS: WB donors presenting a decrease in either hemoglobin (Hb) or ferritin levels were offered to switch to plateletpheresis with or without iron supplementation. We analyzed the effect of this intervention on deferral rates for an insufficient Hb level in 168 donors. Further, we assessed how this intervention affected Hb and ferritin levels, anemia occurrence, and platelet (PLT) concentrate yields in the donors who presented at least four successive times for thrombapheresis. RESULTS: Switching WB donors to repetitive plateletpheresis procedures resulted in an increase of median Hb (+12 g/L, p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2012.03584.x