Preoperative thrombocytosis is associated with survival after surgery for colorectal cancer

• Published in: Journal of surgical oncology 2012-12, Vol.106 (7), p.887-891
• Main Authors: Ishizuka, Mitsuru, Nagata, Hitoshi, Takagi, Kazutoshi, Iwasaki, Yoshimi, Kubota, Keiichi
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - mortality; Colorectal Neoplasms - surgery; Female; Humans; Kaplan-Meier Estimate; Male; Medical treatment; Middle Aged; Multivariate analysis; Platelet Count; Retrospective Studies; ROC Curve; Surgery; survival after surgery; Survival Rate; systemic inflammatory response; thrombocytosis; Thrombocytosis - complications; Thrombocytosis - mortality; Thrombocytosis - pathology; Treatment Outcome
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.23163

Objective To evaluate the influence of preoperative thrombocytosis on survival after surgery in patients with colorectal cancer (CRC). Methods Four hundred fifty‐three patients who had undergone CRC surgery were retrospectively identified from institutional database. On the basis of receiver operating characteristic (ROC) curve analysis, they were classified into two groups: Group A, with a preoperative platelet count of ≤300 (×109/L), and Group B, with a preoperative platelet count of >300 (×109/L). Uni‐ and multivariate analyses were performed to evaluate the relationship to overall survival. Kaplan–Meier analysis and log rank test were used to compare the survival curves between groups A and B. Results There was a significant difference in overall survival between the two groups (P = 0.007). Multivariate analysis of selected preoperative clinicolaboratory characteristics showed that overall survival was associated with the platelet count (Group A/B) (odds ratio, 1.642; 95% CI, 1.025–2.629; P = 0.039) as well as the number of tumors (1/≥2), and the serum levels of C‐reactive protein (CRP) and carcinoembryonic antigen (CEA). Conclusion Preoperative thrombocytosis is associated with survival after surgery in CRC patients, and is able to divide such patients into two independent groups before surgery. J. Surg. Oncol. 2012; 106:887–891. © 2012 Wiley Periodicals, Inc.