Perceived treatment group affects behavioral and neural responses to visceral pain in a deceptive placebo study

Background  To assess effects of perceived treatment (i.e. drug vs placebo) on behavioral and neural responses to rectal pain stimuli delivered in a deceptive placebo condition. Methods  This fMRI study analyzed the behavioral and neural responses during expectation‐mediated placebo analgesia in a r...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2012-10, Vol.24 (10), p.935-e462
Main Authors: Kotsis, V., Benson, S., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E. R., Elsenbruch, S.
Format: Article
Language:English
Subjects:
Adult
Analgesia
Analgesics
Analgesics - pharmacology
Anticipation, Psychological - physiology
Brain - drug effects
Brain - physiology
Clinical trials
Cortex (cingulate)
Cortex (insular)
Double-Blind Method
Drugs
expectations
Female
Functional magnetic resonance imaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Pain Measurement
Pain perception
Placebo Effect
placebo response
Rectum
research design
visceral pain
Visceral Pain - drug therapy
Visceral Pain - psychology
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Summary:Background  To assess effects of perceived treatment (i.e. drug vs placebo) on behavioral and neural responses to rectal pain stimuli delivered in a deceptive placebo condition. Methods  This fMRI study analyzed the behavioral and neural responses during expectation‐mediated placebo analgesia in a rectal pain model. In N = 36 healthy subjects, the blood oxygen level‐dependent (BOLD) response during cued anticipation and painful stimulation was measured after participants were informed that they had a 50% chance of receiving either a potent analgesic drug or an inert substance (i.e., double‐blind administration). In reality, all received placebo. We compared responses in subjects who retrospectively indicated that they received the drug and those who believed to have received placebo. Key Results  55.6% (N = 20) of subjects believed that they had received a placebo, whereas 36.1% (N = 13) believed that they had received a potent analgesic drug. Subjects who were uncertain (8.3%, N = 3) were excluded. Rectal pain‐induced discomfort was significantly lower in the perceived drug treatment group (P 
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2012.01968.x