Anemia at 1 Year After Kidney Transplantation Has a Negative Long-term Impact on Graft and Patient Outcomes

• Published in: Transplantation proceedings 2012-11, Vol.44 (9), p.2593-2595
• Main Authors: Marcén, R, Galeano, C, Fernandez-Rodriguez, A, Jiménez, S, Teruel, J.L, Burgos, F.J, Quereda, C
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Anemia - blood; Anemia - drug therapy; Anemia - epidemiology; Anemia - mortality; Biomarkers - blood; Cardiovascular Diseases - epidemiology; Creatinine - blood; Cyclosporine - adverse effects; Female; Graft Survival; Hematinics - therapeutic use; Hemoglobins - metabolism; Humans; Immunosuppressive Agents - adverse effects; Incidence; Kaplan-Meier Estimate; Kidney Transplantation - adverse effects; Kidney Transplantation - mortality; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Proportional Hazards Models; Risk Factors; Serum Albumin - metabolism; Serum Albumin, Human; Spain - epidemiology; Surgery; Time Factors; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2012.09.033

Abstract Background Anemia, a common complication after kidney transplantation, has a controversial impact on graft or patient survivals or the appearance of cardiovascular disease. The present study investigated the incidence and risk factors for anemia in the first year after transplantation and its effects on graft and patient outcomes. Patients and Methods Among 389 patients transplanted between January 2000 and June 2008, the 331 with functioning grafts at 1 year were included in the study. The mean follow-up was 84 ± 31.8 months. Anemia was defined according to the World Health Organization as a hemoglobin < 13 g/dL in men and < 12 g/dL in women. Results The 88 patients (26.6%) with anemia included 21 (6.3%) who were receiving erythropoiesis stimulant agents. The predictive factors for anemia were: initial immunosuppression with cyclosporine (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.25−3.47; P = .005), serum creatinine (mg/dL) at discharge (OR 1.7; CI 95% 1.26−2.15 P = .000), and 1-year serum albumin (g/dL; OR 0.21; CI 95% 0.10−0.71 P = .001). Donor age in years (OR 1.02; CI 95% 1.00−1.03, P = .054) was close to significance. Cox multivariate analysis showed 1-year hemoglobin (g/dL) to be associated with graft (hazard ratio [HR] 0.81, 95% CI 0.69−0.96, P = .003) and patient survivals after adjusting for other variables (HR 0.74; 95% CI 0-59-0.96, P = .023). But it was only a cardiovascular risk factor when serum creatinine was not included in the model. Conclusions Approximately one quarter of patients with functioning grafts show anemia at 1-year. Graft function, initial immunosuppression, serum albumin, and perhaps donor age were risk factors for anemia, which had a negative impact on graft and patient survival, and could be a risk factor for cardiovascular disease.