PTEN: an intercellular peacekeeper?

It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor su...

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Bibliographic Details
Published in:Science signaling 2012-11, Vol.5 (250), p.pe50-pe50
Main Author: Leslie, Nick R
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Exosomes - secretion
Humans
Neoplasm Proteins - secretion
Neoplasms - metabolism
PTEN Phosphohydrolase - secretion
Signal Transduction
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Summary:It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.2003685