Clinical and histological prognostic factors in locally advanced oral cavity cancers treated with primary surgery

Summary Objective The primary objective of this study was to determine the clinical and pathological prognostic factors in locally advanced oral cavity cancers treated by primary surgery. Methods All patients treated by primary surgery with free-flap reconstruction for locally advanced oral cavity s...

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Published in:European annals of otorhinolaryngology, head and neck diseases head and neck diseases, 2012-12, Vol.129 (6), p.291-296
Main Authors: Vincent, N, Dassonville, O, Chamorey, E, Poissonnet, G, Pierre, C.-S, Nao, E.-E.-M, Peyrade, F, Benezery, K, Viel, D, Sudaka, A, Marcy, P.-Y, Vallicioni, J, Demard, F, Santini, J, Bozec, A
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Female
Free flaps
Humans
Male
Middle Aged
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Mouth Neoplasms - surgery
Oral cavity
Otolaryngology
Prognosis
Retrospective Studies
Squamous cell carcinoma
Surgery
Survival Rate
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Summary:Summary Objective The primary objective of this study was to determine the clinical and pathological prognostic factors in locally advanced oral cavity cancers treated by primary surgery. Methods All patients treated by primary surgery with free-flap reconstruction for locally advanced oral cavity squamous cell carcinoma in our institution between 2000 and 2010 were included in this retrospective study. Overall, cause-specific and locoregional disease-free survivals were determined by Kaplan-Meier analyses. Clinical and histological prognostic factors were assessed by univariate (Log Rank tests) and multivariate (Cox models) analyses. Results A total of 149 patients (102 men and 47 women; mean age = 61.3 ± 12.1 years) were included in the study. Five-year overall, cause-specific and locoregional disease-free survivals were 55%, 68% and 71%, respectively. Age, comorbidity and tumour size (histological evaluation) were significantly correlated with overall survival ( P < 0.05). Age, tumour size, bone invasion and surgical margins were significantly correlated with locoregional disease-free survival ( P < 0.05). Conclusion The main prognostic factors identified in this study were clinical (age and comorbidity) and histological (pathological tumour size, bone invasion and surgical margins).
ISSN:1879-7296
1879-730X
DOI:10.1016/j.anorl.2012.01.004