The effect of temperature on di(2‐ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions

Summary Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2‐ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA® Infusion sets, into lipid and non‐lipid infusates. Two propofol admixtures (Diprivan® 1%, Propoven...

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Bibliographic Details
Published in:Anaesthesia 2012-05, Vol.67 (5), p.514-520
Main Authors: Rose, R. J., Priston, M. J., Rigby‐Jones, A. E., Sneyd, J. R.
Format: Article
Language:English
Subjects:
Analysis of Variance
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Chromatography
Diethylhexyl Phthalate - chemistry
Drug Contamination
Emulsions
Emulsions - chemistry
Equipment Contamination
Fat Emulsions, Intravenous - chemistry
Feeding
Hot Temperature
Infusions, Intravenous - instrumentation
Leaching
Lipids
Maximum Allowable Concentration
Medical equipment
Medical sciences
Neonates
Phospholipids - chemistry
Phthalates
Plasticizers - chemistry
Polyvinyl chloride
Polyvinyl Chloride - chemistry
Propofol
Sodium Chloride
Soybean Oil - chemistry
Temperature
Vinyl chloride
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Summary:Summary Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2‐ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA® Infusion sets, into lipid and non‐lipid infusates. Two propofol admixtures (Diprivan® 1%, Propoven® 1%), Intralipid® 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h−1 for 6 h at 24, 32 and 37 °C. In addition, TIVA sets were filled with 2 ml infusates, sealed and incubated at 24 and 37 °C for 6 h. Di(2‐ethylhexyl) phthalate was detected in all lipid infusates after dynamic infusion and static contact, and in 0.9% saline after dynamic infusion at 37 °C. At 32 and 37 °C, the quantity of di(2‐ethylhexyl) phthalate leaching into the lipid infusates may exceed the recommended maximum exposure amount set by the European Union for DEHP of 20–48 μg.kg−1.day−1 if lipid based infusates are used for sedation or intravenous feeding of infants or neonates.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2011.07006.x