Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals

The management of overweight subjects by interventions aimed at reducing inflammation is highly desirable. To date, observational studies have identified a link between increased dietary antioxidant intake and reduced cardiovascular morbidity. However, direct trial evidence regarding the ability of...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2013, Vol.24 (1), p.163-168
Main Authors: McEneny, Jane, Wade, Lauren, Young, Ian S, Masson, Lindsey, Duthie, Garry, McGinty, Ann, McMaster, Cyril, Thies, Frank
Format: Article
Language:English
Subjects:
amyloid
antioxidant activity
Apolipoprotein A-I - blood
Aryldialkylphosphatase - blood
Carotenoids - blood
Carotenoids - therapeutic use
cholesterol acyltransferase
Cholesterol Ester Transfer Proteins - blood
cholesteryl ester transfer protein
compliance
diet
high density lipoprotein
Humans
inflammation
Lipoproteins, HDL - blood
lycopene
Middle Aged
morbidity
observational studies
overweight
Overweight - blood
Overweight - drug therapy
Phosphatidylcholine-Sterol O-Acyltransferase - blood
Serum Amyloid A Protein - analysis
ultracentrifugation
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Summary:The management of overweight subjects by interventions aimed at reducing inflammation is highly desirable. To date, observational studies have identified a link between increased dietary antioxidant intake and reduced cardiovascular morbidity. However, direct trial evidence regarding the ability of antioxidants to influence inflammation is lacking. Therefore, this study examined lycopene's ability to lower systemic and high-density lipoprotein (HDL)-associated inflammation in moderately overweight middle-aged subjects. Serum was collected before and after a 12-week intervention from 54 moderately overweight, middle-aged individuals. Subjects were randomised to one of three groups: control diet (
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2012.03.015