Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: A randomized placebo-controlled clinical trial

Abstract Objective Obsessive–compulsive disorder is a common neuropsychiatric condition. Although various pharmaceutical agents are available for the treatment of obsessive–compulsive disorder, psychiatrists often find that many patients cannot tolerate the side effects of these medications, the pat...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2012-09, Vol.28 (9), p.892-895
Main Authors: Sayyah, Mehdi, M.D, Olapour, Alireza, M.D, Saeedabad, Yashar shahhosseini, M.D, Yazdan Parast, Rezvan, M.D, Malayeri, Alireza, Ph.D
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Behavior
Biological and medical sciences
Clinical trial
Clinical trials
Cognition & reasoning
Dietary Supplements
Double-Blind Method
Drug Therapy, Combination
Feeding. Feeding behavior
Female
Fluoxetine - therapeutic use
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Gene expression
Hospitals
Humans
Kinases
Male
Neuroses
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - drug therapy
Prospective Studies
Psychiatric Status Rating Scales
Serotonin
Serotonin Uptake Inhibitors - therapeutic use
Side effects
Trace elements
Trace Elements - therapeutic use
Treatment Outcome
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Zinc
Zinc - therapeutic use
Zinc Sulfate - therapeutic use
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Summary:Abstract Objective Obsessive–compulsive disorder is a common neuropsychiatric condition. Although various pharmaceutical agents are available for the treatment of obsessive–compulsive disorder, psychiatrists often find that many patients cannot tolerate the side effects of these medications, the patients do not respond properly to the treatment, or the medications lose their effectiveness after a period of treatment. The augmentation with safe supplementation of medication, such as with trace elements, may be a solution to some of these problems. Methods This study was a prospective, double-blinded, 8-wk trial. Twelve patients were given fluoxetine (20 mg/d) plus zinc (440 mg/d) and 11 patients were given fluoxetine plus placebo for 8 wk. Results Both groups showed a decrease in the mean Yale–Brown Obsessive–Compulsive Scale score. Based on t tests, in weeks 2 and 8, patients treated with fluoxetine plus zinc had significantly lower scores than those treated with fluoxetine plus placebo. Conclusion The results show that zinc, as adjuvant agent for obsessive–compulsive disorder, produces improved outcomes.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2011.11.027