Infections Acquired by Adults Who Receive Extracorporeal Membrane Oxygenation: Risk Factors and Outcome

• Published in: Infection control and hospital epidemiology 2013-01, Vol.34 (1), p.24-30
• Main Authors: Aubron, Cecile, Cheng, Allen C., Pilcher, David, Leong, Tim, Magrin, Geoff, Cooper, D. Jamie, Scheinkestel, Carlos, Pellegrino, Vince
• Format: Article
• Language: English
• Subjects: Adult; Antibiotics; Australia - epidemiology; Biological and medical sciences; Candidemia - epidemiology; Catheter-Related Infections - epidemiology; Catheter-Related Infections - microbiology; Cross Infection - epidemiology; Cross Infection - etiology; Cross Infection - microbiology; Diseases; Extracorporeal membrane oxygenation; Extracorporeal Membrane Oxygenation - adverse effects; Female; Hospital Mortality; Hospital units; Humans; Incidence; Infections; Intensive Care Units; Length of Stay; Male; Medical sciences; Middle Aged; Miscellaneous; Mortality; Multivariate Analysis; Nursing; Original Article; Pneumonia, Ventilator-Associated - epidemiology; Pneumonia, Ventilator-Associated - microbiology; Predisposing factors; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retrospective Studies; Risk Factors; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; Weaning
• ISSN: 0899-823X; 1559-6834
• DOI: 10.1086/668439

Objectives. To analyze infectious complications that occur in patients who receive extracorporeal membrane oxygenation (ECMO), associated risk factors, and consequences on patient outcome. Design. Retrospective observational survey from 2005 through 2011. Participants and Setting. Patients who required ECMO in an Australian referral center. Methods. Cases of bloodstream infection (BSI), catheter-associated urinary tract infection (CAUTI), and ventilator-associated pneumonia (VAP) that occurred in patients who received ECMO were analyzed. Results. A total of 146 ECMO procedures were performed for more than 48 hours in 139 patients, and 36 patients had a total of 46 infections (30.1 infectious episodes per 1,000 days of ECMO). They included 24 cases of BSI, 6 of them secondary to VAP; 23 cases of VAP; and 5 cases of CAUTI. The most frequent pathogens were Enterobacteriaceae (found in 16 of 46 cases), and Candida was the most common cause of BSI (in 9 of 24 cases). The Sequential Organ Failure Assessment score before ECMO initiation and the number of days of support were independently associated with a risk of BSI, with odds ratios of 1.23 (95% confidence interval [CI], 1.03–1.47; ) and 1.08 (95% CI, 1.03–1.19]; ), respectively. Infected patients did not have a significantly higher mortality compared with uninfected patients (41.7% vs 32%; ), but intensive care unit length of stay (16 days [interquartile range, 8–26 days] vs 11 days [IQR, 4–19 days]; ) and hospital length of stay (33.5 days [interquartile range, 15.5–55.5] vs 24 days [interquartile range, 9–42 days]; ) were longer. Conclusion. The probability of infection increased with the duration of support and the severity of illness before initiation of ECMO. Infections affected length of stay but did not have an impact on mortality.