Elevated resting heart rate is an independent predictor of all-cause death and cardiovascular events in Japanese ambulatory hemodialysis patients

Background Elevated heart rate (HR) is an independent risk factor for all-cause death or cardiovascular events in non-hemodialysis subjects; however, the clinical significance of elevated HR in hemodialysis patients is not well studied. Methods We prospectively evaluated the relationship between HR...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental nephrology 2012-12, Vol.16 (6), p.938-944
Main Authors: Inoue, Taku, Tokuyama, Kiyoyuki, Yoshi, Shinichiro, Nagayoshi, Naoko, Iseki, Chiho, Iseki, Kunitoshi
Format: Article
Language:English
Subjects:
Aged
Ambulatory Care
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cohort Studies
Female
Follow-Up Studies
Heart Rate - physiology
Humans
Japan - epidemiology
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality - trends
Nephrology
Original Article
Predictive Value of Tests
Prospective Studies
Regression Analysis
Renal Dialysis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - therapy
Rest - physiology
Risk Factors
Sensitivity and Specificity
Survival Rate
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Elevated heart rate (HR) is an independent risk factor for all-cause death or cardiovascular events in non-hemodialysis subjects; however, the clinical significance of elevated HR in hemodialysis patients is not well studied. Methods We prospectively evaluated the relationship between HR and adverse outcome in a total of 229 ambulatory hemodialysis patients (57 % men; mean age 62.2 years) recruited from two dialysis clinics in 2009. Mean (SD) HR of this cohort was 74.1 (11.0) beats per minute (bpm). Results Receiver operating characteristic curves identified an HR cut-off level of ≥80 bpm for increased adverse outcome. After a mean follow-up of 525 days (range 7–760 days) a total of 30 primary endpoints (21 all-cause deaths, 4 acute coronary syndromes and 8 strokes) and 38 secondary endpoints (30 primary endpoints, 8 congestive heart failures, and 5 other cardiovascular events) were detected. Cox regression analysis revealed that HR >80 bpm was not an independent predictor of primary endpoints [hazard ratio 1.81, 95 % confidence interval (CI) 0.79–4.11, p  = NS], but of secondary endpoints (hazard ratio 2.01, 95 % CI 1.01–4.22, p  
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-012-0641-3