Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease

In a multi-centre study, we sought to determine whether extent of disease on high-resolution CT (HRCT) lung, reported using a simple grading system, is predictive of decline and mortality in SSc-related interstitial lung disease (SSc-ILD), independently of pulmonary function tests (PFTs) and other p...

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Published in:Rheumatology (Oxford, England) England), 2013-01, Vol.52 (1), p.155-160
Main Authors: Moore, Owen A, Goh, Nicole, Corte, Tamera, Rouse, Hannah, Hennessy, Oliver, Thakkar, Vivek, Byron, Jillian, Sahhar, Joanne, Roddy, Janet, Gabbay, Eli, Youssef, Peter, Nash, Peter, Zochling, Jane, Proudman, Susanna M, Stevens, Wendy, Nikpour, Mandana
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Lung - diagnostic imaging
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - mortality
Male
Middle Aged
Predictive Value of Tests
Prognosis
Radiography
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnostic imaging
Scleroderma, Systemic - mortality
Severity of Illness Index
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Summary:In a multi-centre study, we sought to determine whether extent of disease on high-resolution CT (HRCT) lung, reported using a simple grading system, is predictive of decline and mortality in SSc-related interstitial lung disease (SSc-ILD), independently of pulmonary function tests (PFTs) and other prognostic variables. SSc patients with a baseline HRCT performed at the time of ILD diagnosis were identified. All HRCTs and PFTs performed during follow-up were retrieved. Demographic and disease-related data were prospectively collected. HRCTs were graded according to the percentage of lung disease: >20%: extensive; 20%) on HRCT at baseline, reported using a semi-quantitative grading system, is associated with a three-fold increased risk of deterioration or death in SSc-ILD, compared with limited disease. Serial PFTs are informative in follow-up of patients.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kes289