Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate

Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 femal...

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Bibliographic Details
Published in:Lupus 2012-12, Vol.21 (14), p.1515-1521
Main Authors: Overman, CL, Hartkamp, A, Bossema, ER, Bijl, M, Godaert, GLR, Bijlsma, JWJ, Derksen, RHWM, Geenen, R
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate - blood
Fatigue
Fatigue - epidemiology
Fatigue - etiology
Female
Glucocorticoids - therapeutic use
Health psychology
Humans
Immunology
Inventories
Luminescent Measurements
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - physiopathology
Middle Aged
Physiology
Prednisone
Prednisone - therapeutic use
Psychometrics
Remission (Medicine)
Rheumatology
Systemic lupus erythematosus
Womens health
Young Adult
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Summary:Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p ≤ 0.001) than healthy women and more often had below-normal DHEAS levels (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203312459105