Divergent brain network connectivity in amyotrophic lateral sclerosis

Abstract Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional co...

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Bibliographic Details
Published in:Neurobiology of aging 2013-02, Vol.34 (2), p.419-427
Main Authors: Agosta, Federica, Canu, Elisa, Valsasina, Paola, Riva, Nilo, Prelle, Alessandro, Comi, Giancarlo, Filippi, Massimo
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - physiopathology
Amyotrophic Lateral Sclerosis - psychology
Brain - physiopathology
Brain Mapping
Cognitive ability
Cognitive impairment
Cortex (frontal)
Cortex (parietal)
Dementia disorders
Executive function
Executive Function - physiology
Executive functions
Female
Functional magnetic resonance imaging
Humans
Injuries
Internal Medicine
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net - physiopathology
Nervous system
Neural networks
Neurology
Neuropsychological Tests
Resting state functional MRI
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Summary:Abstract Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional connectivity and executive functions was assessed in 16 patients with neuropsychological assessment. ALS patients compared with control subjects showed a decreased connectivity of the right orbitofrontal cortex, and an enhanced connectivity of the left precuneus in the default mode network; a decreased connectivity of the left inferior frontal cortex, and an increased connectivity of the right angular gyrus in the right frontoparietal network; and an increased connectivity of the parietal cortex in the left frontoparietal network. The enhanced parietal connectivity was associated with the clinical and cognitive deficits of the patients. In ALS, an alteration of large-scale functional brain networks associated with cognition does occur, even in the absence of overt dementia. The increased parietal connectivity may have a role in an attempt to maintain cognitive efficiency in the presence of structural frontotemporal injury.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2012.04.015