A positive family history for premature cardiovascular disease identifies patients prone to recurrent arterial thrombotic events

Background: Cardiovascular disease (CVD) is characterized by slow progressive atherosclerosis and arterial thrombotic events, leading to occlusions. Whether either of these presentations is more likely in patients with a genetic predisposition for CVD is still unknown. We suggest that a genetic pred...

Full description

Saved in:
Bibliographic Details
Published in:European journal of preventive cardiology 2012-12, Vol.19 (6), p.1465-1473
Main Authors: Mulders, Ties A, Maurissen, Lisbeth FA, Meyer, Zainna, Hameeteman, Marijn, van der Donk, Christel, Kroon, Abraham A, Ferreira, Isabel, Stehouwer, Coen DA, Hackeng, Tilman M, Pinto-Sietsma, Sara-Joan
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Arterial Occlusive Diseases - diagnosis
Arterial Occlusive Diseases - epidemiology
Arterial Occlusive Diseases - genetics
Atherosclerosis - epidemiology
Atherosclerosis - genetics
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Disease-Free Survival
Female
Genetic Predisposition to Disease
Heredity
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Netherlands - epidemiology
Pedigree
Phenotype
Proportional Hazards Models
Recurrence
Retrospective Studies
Risk Assessment
Risk Factors
Thrombosis - diagnosis
Thrombosis - epidemiology
Thrombosis - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Cardiovascular disease (CVD) is characterized by slow progressive atherosclerosis and arterial thrombotic events, leading to occlusions. Whether either of these presentations is more likely in patients with a genetic predisposition for CVD is still unknown. We suggest that a genetic predisposition for CVD is related to recurrent events of the same nature. Methods: We retrospectively investigated 275 patients with premature CVD and divided them in two groups according to their first event: an arterial thrombotic event or stable atherosclerosis. We used a Cox proportional-hazards model to estimate the effect of a positive family history for CVD on recurrent events of the same nature. This was tested in the entire cohort and in patients with coronary artery disease only. Results: Patients with a first arterial thrombotic event and a positive family history had a threefold increased risk for a recurrent event of the same nature, compared to patients with a negative family history (hazard ratio 3.00, 95% confidence interval 1.32–6.81); p 
ISSN:2047-4873
2047-4881
DOI:10.1177/1741826711422989