Continual Gram-Negative Bacterial Challenge Accelerates Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in un...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2013-01, Vol.35 (1), p.28-34
Main Authors: Kawato, Takayuki, Tanaka, Hideki, Tabuchi, Masaki, Ooshima, Kana, Nakai, Kumiko, Yamashita, Yoshihisa, Maeno, Masao
Format: Article
Language:English
Subjects:
Age Factors
Animals
Biomarkers - blood
Blood Pressure
Brain - pathology
chronic infections
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
Gram-negative bacteria
Gram-Negative Bacteria - pathogenicity
Gram-Negative Bacterial Infections - complications
Hypertension - complications
Hypertension - physiopathology
lipopolysaccharide
Lipopolysaccharides - administration & dosage
Lipopolysaccharides - toxicity
Nitrogen Oxides - blood
Rats
Rats, Inbred SHR
stroke
Stroke - blood
Stroke - etiology
Stroke - microbiology
Stroke - pathology
stroke-prone spontaneously hypertensive rats (SHRSP)
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2012.689042