Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo

Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2013-02, Vol.24 (2), p.475-483
Main Authors: Cheng, Yu-Ting, Wu, Chi-Hao, Ho, Cheng-Ying, Yen, Gow-Chin
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidant enzymes
antioxidants
apigenin
Catechin
Catechin - pharmacology
Cell Line
Cyclooxygenase 1 - genetics
digestive system diseases
DNA Damage - drug effects
gastric mucosa
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastric ulcer
Glutathione - metabolism
glutathione peroxidase
Glutathione Peroxidase - metabolism
glutathione-disulfide reductase
heme oxygenase (decyclizing)
Heme Oxygenase-1 - metabolism
HO-1
Humans
intestinal mucosa
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Ketoprofen
Ketoprofen - adverse effects
L-Lactate Dehydrogenase - metabolism
lipid peroxidation
Lipid Peroxidation - drug effects
Male
malvidin
medicine
Membrane Proteins - genetics
NF-E2-Related Factor 2 - metabolism
Nrf2
NSAID
Oxidative Stress - drug effects
phytochemicals
Protective Agents - pharmacology
protective effect
protein synthesis
Rats
Rats, Sprague-Dawley
reactive oxygen species
Reactive Oxygen Species - metabolism
sulfhydryl groups
Up-Regulation
Western blotting
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Summary:Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2012.01.010