Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial)

Abstract This study evaluates bone quality in sinus augmented with autogenous bone with or without platelet rich plasma (PRP) mix. 15 partially edentulous patients requiring maxillary sinus floor augmentation, followed by implant insertion were studied. In Group I, 5 patients underwent maxillary sin...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2013-02, Vol.42 (2), p.249-255
Main Authors: Khairy, N.M, Shendy, E.E, Askar, N.A, El-Rouby, D.H
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Bone Density - drug effects
bone regeneration
Bone Regeneration - drug effects
Bone Transplantation
Dental Implantation, Endosseous
Dentistry
Female
Follow-Up Studies
Guided Tissue Regeneration, Periodontal
Humans
Male
maxillary sinus floor augmentation
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Platelet-Derived Growth Factor - pharmacology
Platelet-Rich Plasma
Sinus Floor Augmentation - methods
Statistics, Nonparametric
Surgery
Treatment Outcome
Young Adult
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Summary:Abstract This study evaluates bone quality in sinus augmented with autogenous bone with or without platelet rich plasma (PRP) mix. 15 partially edentulous patients requiring maxillary sinus floor augmentation, followed by implant insertion were studied. In Group I, 5 patients underwent maxillary sinus lifting with autogenous bone augmentation and implant insertion at 6 months post grafting. In Group II, 10 patients underwent maxillary sinus lifting with autogenous bone augmentation mixed with PRP prepared from the patient's own blood with implant insertion at 4 or 6 months post grafting ( n = 5 for each implantation time). A core biopsy was taken at the time of implant placement for histological and histomorphometric evaluation. Immediately and 3 months after implantation, Group I showed the statistically significant highest mean bone density ( p = 0.046 and 0.022, respectively). At 6 months post-implantation, Group II showed the statistically significant highest mean bone density ( p = 0.041). Histomorphometric analysis showed that Group I had the statistically significant highest mean value (39.5 ± 7.4; p = 0.003). Enrichment with PRP did not significantly improve bone density or morphometric value at 3 months post grafting. PRP enriched bone grafts were associated with superior bone density at 6 months post grafting.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2012.09.009