Granger causality analysis of functional connectivity of spiking neurons in orofacial motor cortex during chewing and swallowing

Primate feeding behavior is characterized by a series of jaw movement cycles of different types making it ideal for investigating the role of motor cortex in controlling transitions between different kinematic states. We recorded spiking activity in populations of neurons in the orofacial portion of...

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Bibliographic Details
Published in:2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2012-01, Vol.2012, p.4587-4590
Main Authors: Takahashi, K., Pesce, L., Iriarte-Diaz, J., Sanggyun Kim, Coleman, T. P., Hatsopoulos, N. G., Ross, C. F.
Format: Article
Language:English
Subjects:
Arrays
Cranium
Educational institutions
History
Kinematics
Neurons
USA Councils
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Summary:Primate feeding behavior is characterized by a series of jaw movement cycles of different types making it ideal for investigating the role of motor cortex in controlling transitions between different kinematic states. We recorded spiking activity in populations of neurons in the orofacial portion of primary motor cortex (MIo) of a macaque monkey and, using a Granger causality model, estimated their functional connectivity during transitions between chewing cycles and from chewing to swallowing cycles. We found that during rhythmic chewing, the network was dominated by excitatory connections and exhibited a few "out degree" hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more "in degree" hub neurons emerged. These results suggest that networks of neurons in MIo change their operative states with changes in kinematically defined behavioral states.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2012.6346988