Fruit and vegetable intake and breast cancer risk: a case for subtype-specific risk?

Here, Thomson and Thomson comment on Jung and colleagues' study that reports no overall effect of fruit and vegetable consumption on breast cancer risk among women in the large, long-term Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project). When the authors considered ho...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2013-02, Vol.105 (3), p.164-165
Main Authors: Thomson, Cynthia A, Thompson, Patricia A
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - prevention & control
Feeding Behavior
Female
Fruit
Fruits
Humans
Oncology
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Risk assessment
Vegetables
Womens health
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Summary:Here, Thomson and Thomson comment on Jung and colleagues' study that reports no overall effect of fruit and vegetable consumption on breast cancer risk among women in the large, long-term Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project). When the authors considered hormone-responsive, estrogen receptor (ER)-positive patients separately from the nonhormonal, ER-negative patients under a hypothesis of separate etiology, a statistically significant protective effect of fruit and vegetable consumption was observed for risk of ER-negative, but not ER-positive breast cancer. Most striking, the authors provide evidence that the protective effect of fruit and vegetable consumption for ER-negative breast cancer, in terms of magnitude and direction, were largely consistent across the 20 pooled studies. With these findings, the authors add to the growing number of studies reporting the differential effect of risk factors, including the classic breast cancer reproductive risk factors such as age of first pregnancy, when breast cancer is considered as separate subgroups such as ER-positive, ER-negative and triple negative breast cancer.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djs640