In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants

Drug resistance in malaria is a recurring subject that threatens public health globally. There is an urgent need to seek new antimalarial agents. This study seeking new antimalarials from medicinal plants is guided by ethnobotany. Medicinal plants of the Luo and Kuria ethnic groups of Kenya with hig...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ethnopharmacology 2012-12, Vol.144 (3), p.779-781
Main Authors: Owuor, B.O., Ochanda, J.O., Kokwaro, J.O., Cheruiyot, A.C., Yeda, R.A, Okudo, C.A., Akala, H.M.
Format: Article
Language:English
Subjects:
Ageratum conyzoides
Antimalarials - pharmacology
Antiplasmodial activity
chloroquine
drug resistance
fluorescence
inhibitory concentration 50
Kenya
Magnoliopsida
malaria
Medicinal plants
Medicine, African Traditional
nationalities and ethnic groups
Ocimum
plant extracts
Plant Extracts - pharmacology
Plants, Medicinal
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plectranthus
Plectranthus barbatus
public health
Traditional medicine Africa
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drug resistance in malaria is a recurring subject that threatens public health globally. There is an urgent need to seek new antimalarial agents. This study seeking new antimalarials from medicinal plants is guided by ethnobotany. Medicinal plants of the Luo and Kuria ethnic groups of Kenya with high usage reports were screened in vitro for their antiplasmodial activity using the SYBR Green I fluorescence assay (MSF assay). The IC50's for drugs and total plant extracts ranged from 0.01217 to 10.679mg/ml. Extracts were more active on chloroquine sensitive than resistant Plasmodium falciparum strains. Tylosema fassoglense, Ageratum conyzoides and Ocimum kilimandscharicum exhibited promising results. Plectranthus barbatus did not show activity. Ethnobotanical knowledge was sufficiently reliable for identifying plant extracts with antiplasmodial activity. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2012.09.045