PTH—A Particularly Tricky Hormone: Why Measure It at All in Kidney Patients?

Plasma parathyroid hormone (PTH) concentrations are commonly measured in the context of CKD, as PTH concentration elevation is typical in this clinical context. Much has been inferred from this raised PTH concentration tendency, both about the state of skeletal integrity and health and also about th...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2013-02, Vol.8 (2), p.299-312
Main Authors: Garrett, Giorgia, Sardiwal, Sunita, Lamb, Edmund J, Goldsmith, David J A
Format: Article
Language:English
Subjects:
Diagnostic Tests, Routine
Hematologic Tests - utilization
Humans
Parathyroid Hormone - blood
Renal Insufficiency, Chronic - blood
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Summary:Plasma parathyroid hormone (PTH) concentrations are commonly measured in the context of CKD, as PTH concentration elevation is typical in this clinical context. Much has been inferred from this raised PTH concentration tendency, both about the state of skeletal integrity and health and also about the potential clinical outcomes for patients. However, we feel that reliance on PTH concentrations alone is a dangerous substitute for the search for, and use of, more precise and reliable biomarkers. In this article, we rehearse these arguments, bringing together patient-level and analytical considerations for the first time.
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.09580911