Noise-Induced Hearing Loss (NIHL) as a Target of Oxidative Stress-Mediated Damage: Cochlear and Cortical Responses after an Increase in Antioxidant Defense

This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q 10 analog (Q ter ) was used. We analyzed auditory function, cochlear oxidat...

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Bibliographic Details
Published in:The Journal of neuroscience 2013-02, Vol.33 (9), p.4011-4023
Main Authors: Fetoni, Anna Rita, De Bartolo, Paola, Eramo, Sara Letizia Maria, Rolesi, Rolando, Paciello, Fabiola, Bergamini, Christian, Fato, Romana, Paludetti, Gaetano, Petrosini, Laura, Troiani, Diana
Format: Article
Language:English
Subjects:
Accessory Atrioventricular Bundle
Acoustic Stimulation
Aldehydes - metabolism
Analysis of Variance
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Antioxidants - therapeutic use
Auditory Pathways - drug effects
Auditory Pathways - pathology
Auditory Pathways - ultrastructure
Brain Injuries - drug therapy
Brain Injuries - etiology
Brain Injuries - pathology
Cochlea - pathology
Cochlea - physiopathology
Disease Models, Animal
Ethidium - analogs & derivatives
Ethidium - metabolism
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - physiology
Hair Cells, Auditory - pathology
Hair Cells, Auditory - ultrastructure
Hearing Loss, Noise-Induced - complications
Hearing Loss, Noise-Induced - drug therapy
Hearing Loss, Noise-Induced - pathology
Male
Oxidative Stress - drug effects
Oxidative Stress - physiology
Rats
Rats, Wistar
Silver Staining
Ubiquinone - analogs & derivatives
Ubiquinone - metabolism
Ubiquinone - pharmacology
Ubiquinone - therapeutic use
Visual Cortex - drug effects
Visual Cortex - pathology
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