Modified Foxp3 mRNA protects against asthma through an IL-10–dependent mechanism

Chemically modified mRNA is capable of inducing therapeutic levels of protein expression while circumventing the threat of genomic integration often associated with viral vectors. We utilized this novel therapeutic tool to express the regulatory T cell transcription factor, FOXP3, in a time- and sit...

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Bibliographic Details
Published in:The Journal of clinical investigation 2013-03, Vol.123 (3), p.1216-1228
Main Authors: Mays, Lauren E., Ammon-Treiber, Susanne, Mothes, Benedikt, Alkhaled, Mohammed, Rottenberger, Jennifer, Müller-Hermelink, Eva Sophie, Grimm, Melanie, Mezger, Markus, Beer-Hammer, Sandra, von Stebut, Esther, Rieber, Nikolaus, Nürnberg, Bernd, Schwab, Matthias, Handgretinger, Rupert, Idzko, Marco, Hartl, Dominik, Kormann, Michael S.D.
Format: Article
Language:English
Subjects:
Airway Remodeling
Airway Resistance
Allergens
Allergies
Animals
Asthma
Asthma - immunology
Asthma - metabolism
Asthma - prevention & control
Biomedical research
Cell Line
Cytidine - analogs & derivatives
Cytidine - chemistry
Development and progression
Disease
Female
Forkhead Transcription Factors - biosynthesis
Forkhead Transcription Factors - genetics
Gene Expression
Genetic Therapy
Humans
Immunity, Innate
Inflammation
Inflammation Mediators - pharmacology
Inflammation Mediators - physiology
Interleukin-10
Interleukin-10 - metabolism
Interleukin-17 - pharmacology
Interleukin-17 - physiology
Interleukin-23 - pharmacology
Interleukin-23 - physiology
Messenger RNA
Mice
Mice, Inbred BALB C
Mice, Knockout
Physiological aspects
Prevention
Protein expression
Proteins
Pyroglyphidae - immunology
RNA, Messenger - chemistry
RNA, Messenger - genetics
Th17 Cells - immunology
Th17 Cells - metabolism
Th2 Cells - immunology
Th2 Cells - metabolism
Thiouridine - analogs & derivatives
Thiouridine - chemistry
Transcription factors
Transfection
Vectors (Biology)
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